Ипаморелин
Ипаморелин
Ipamorelin — 5 mg
Ipamorelin is a selective pentapeptide GHRP — it activates the ghrelin receptor and triggers a pure GH pulse. It is the most selective GHRP in studies: unlike older GHRP-2 and GHRP-6, it does not significantly increase cortisol or prolactin. A classic partner to CJC-1295.
Parameters
| Compound | Ipamorelin |
| Molecular Formula | C₃₈H₄₉N₉O₅ |
| Molar Mass | ≈ 712 g/mol |
| CAS No. | 170851-70-4 |
| Number of Amino Acids | 5 (pentapeptide) |
| Mechanism | Selective GHS-R1a (ghrelin) agonist |
| Quantity per Vial | 5 mg |
| Purity | ≥ 99% (HPLC) |
| Form | Lyophilized white powder |
What is Ipamorelin
Ipamorelin (Aib-His-D-2-Nal-D-Phe-Lys-NH₂) is a pentapeptide growth hormone secretagogue developed in the late 1990s. It acts on the ghrelin receptor (GHS-R1a) — different from the GHRH receptor that CJC-1295 acts on.
Its defining characteristic is selectivity: a classic study (Raun, 1998) showed that Ipamorelin releases GH at levels comparable to GHRP-6, but without the cortisol, prolactin, or ACTH release characteristic of older secretagogues. It does not increase cortisol or ACTH even at 200 times the effective GH-releasing dose — which is why it has become the preferred GHRP in combined studies.
How it Works
Ipamorelin binds to the ghrelin receptor (GHSR1a) on pituitary cells and triggers calcium-dependent GH release, which amplifies the current GHRH signal — the "releasing" side of the pulse. In combination with CJC-1295 (the "production" side), the two produce a synergistic effect.
Pharmacokinetics
| Parameter | Value |
|---|---|
| Class | selective GHRP (ghrelin agonist) |
| Receptor | GHS-R1a |
| Selectivity | highest among GHRP class |
Reconstitution (laboratory procedure)
The lyophilized powder is reconstituted with bacteriostatic water. The table shows the concentration for a 5 mg vial:
| Water Added | Concentration | 200 µg dose = |
|---|---|---|
| 1 mL | 5 mg/mL | 4 units (0.04 mL) |
| 2 mL | 2.5 mg/mL | 8 units (0.08 mL) |
Add water slowly along the side of the vial; gently swirl the solution without shaking. Calculations are for a U-100 insulin syringe.
Research Dosing Protocols
In a research context, most often in combination with CJC-1295 No DAC, for a synergistic pulsatile GH effect.
The information reflects protocols from scientific publications and is presented solely as reference information — not as instructions for use.
Side Effects (from published studies)
The profile is clean compared to other GHRPs. Possible: mild headache, transient fluid retention, injection site reactions. No significant cortisol/prolactin increase — its main advantage over older secretagogues.
Storage
- Lyophilized: stable at room temperature for transport; for long-term storage — in a dark and dry place (refrigerator for long term).
- After reconstitution: at 2–8°C, use within up to 28 days. Avoid repeated freezing/thawing.
Tested Quality
Each batch undergoes independent laboratory testing for purity and identity (HPLC), with a COA accompanying the product.
Frequently Asked Questions
What form does it come in? Lyophilized powder in a glass vial, vacuum-sealed.
Is bacteriostatic water included? No — it is sold separately.
Why is Ipamorelin preferred over GHRP-2/GHRP-6? Due to its selectivity — it does not increase cortisol or prolactin.
Why is it combined with CJC-1295? The two act on different receptors for a synergistic GH pulse.
How long is it stable after reconstitution? Up to 28 days in the refrigerator.
What is the shelf life? Lyophilized and properly stored — up to 24 months.
FOR LABORATORY RESEARCH USE ONLY. This product is intended exclusively for in vitro scientific and research purposes. It is NOT a drug, food supplement, or cosmetic product. It is NOT intended for human or animal use, consumption, or application. It has not been approved by the FDA, EMA, or any other regulatory body. The information is educational in nature and does not constitute medical advice or instructions for use. By purchasing, you confirm that you are over 18 years of age and that the product will only be used for legitimate research purposes.